Analysis of Ochratoxin a in Serum and Urine of Inhabitants from an Area with Balkan Endemic Nephropathy: a One Month Follow up Study
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چکیده
1 Institute of Oncology, 6 Plovdivsko Pole, Sofia Darvenitza, Bulgaria 2 Unit of Gene-Environment Interactions, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, Consultant, Les Collanges, 07240 Saint Jean Chambre, France 3 Laboratoire de Toxicologie et Sécurité Alimentaire, Ecole Nationale Supérieure d'Agronomie, Avenue de l'Agrobiopole, BP 107, F-31326 Auzeville-Tolosane, Toulouse, France * corresponding author: [email protected] 4 Unité des Toxines Microbiennes, Agence Française de Sécurité Sanitaire des Aliments, Maison Alfort, France 5 National Center of Hygiene, Mycotoxicological Laboratory, 15 Dimitar Nestorov Street,1431 Sofia, Bulgaria
منابع مشابه
Role of exposure analysis in solving the mystery of Balkan endemic nephropathy.
We evaluated the role of exposure analysis in assessing whether ochratoxin A or aristolochic acid are the agents responsible for causing Balkan endemic nephropathy. We constructed a framework for exposure analysis using the lessons learned from the study of endemic goiter within the context of an accepted general model. We used this framework to develop an exposure analysis model for Balkan end...
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BACKGROUND The etiology of Balkan Endemic Nephropathy, (BEN), a tubulointerstitial kidney disease, is unknown. Although this disease is endemic in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, similar manifestations are reported to occur in other regions, for instance Tunisia and Sri Lanka. A number of explanations have been stated including lignites, aristolochic acid, ochrato...
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متن کاملOchratoxin A and β2-Microglobulin in BEN Patients and Controls
Ochratoxin A (OTA) is a mycotoxin naturally occurring in different foods. OTA is arguably a risk factor for Balkan endemic nephropathy (BEN). The aims of this study are to (1) test the OTA-BEN association in BEN-groups and controls and (2) determine whether urine β2-microglobulin, a marker of impaired ability of the kidneys to re-absorb, is related to OTA. BEN patients had significantly higher ...
متن کاملAristolochic Acid- and Ochratoxin A-dna Adducts: Possible Markers of Balkan Endemic Nephropathy and Associated Urothelial Tumors?
The etiology of Balkan endemic nephropathy (BN) is still debated. The similar prevalence of the disease in immigrants and natives in endemic areas points to environmental etiological factors. Viral agents, selenium deficiency, cadmium, lead and long-term exposure to polycyclic aromatic hydrocarbons and amines have received little support. By contrast, BN is amazingly reminiscent of the findings...
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تاریخ انتشار 2003